What is a key understanding for clients taking cyclophosphamide?

Increasing fluid intake to 2-3 liters daily is important for clients taking cyclophosphamide because this medication can cause bladder irritation and increase the risk of hemorrhagic cystitis. Adequate hydration helps dilute the urine, which reduces the concentration of the drug in the bladder and minimizes the risk of urinary tract damage. Ensuring proper fluid intake is a critical aspect of patient management while using this therapy, as it helps protect the urinary system and supports overall renal function.

This understanding highlights the importance of hydration in the context of cyclophosphamide treatment, ensuring that patients are aware of the necessary steps to mitigate side effects typically associated with the medication.